Insider Trading disclosures for Karyopharm Therapeutics Inc

The latest disclosure was made by Richard Paulson in Karyopharm Therapeutics Inc where a trade of 11,694 Common Stock done at an average price of $6.3 was reported to US exchanges on March 4, 2025.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 6.29 per share.	04 Mar 2025	11,694	82,984 (0%)	0%	6.3	73,555	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 6.29 per share.	04 Mar 2025	3,587	29,272 (0%)	0%	6.3	22,562	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Sale of securities on an exchange or to another person at price $ 6.29 per share.	04 Mar 2025	2,793	21,047 (0%)	0%	6.3	17,568	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 6.29 per share.	04 Mar 2025	3,445	34,314 (0%)	0%	6.3	21,669	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 6.29 per share.	04 Mar 2025	3,548	27,414 (0%)	0%	6.3	22,317	Common Stock
Kristin Abate	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 6.29 per share.	04 Mar 2025	571	9,713 (0%)	0%	6.3	3,592	Common Stock
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	20,000	94,678 (0%)	0%		0	Common Stock
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	40,000	40,000	-		-	Stock Option (right to buy)
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	4,583	32,859 (0%)	0%		0	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	10,833	10,833	-		-	Stock Option (right to buy)
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	9,166	9,166	-		-	Stock Option (right to buy)
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	5,416	28,276 (0%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	3,333	21,590 (0%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	6,666	6,666	-		-	Stock Option (right to buy)
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	4,500	4,500	-		-	Stock Option (right to buy)
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	2,250	23,840 (0%)	0%		0	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	10,833	10,833	-		-	Stock Option (right to buy)
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	4,583	37,759 (0%)	0%		0	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	5,416	33,176 (0%)	0%		0	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	9,166	9,166	-		-	Stock Option (right to buy)
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	9,166	9,166	-		-	Stock Option (right to buy)
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	5,000	26,379 (0%)	0%		0	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	4,583	30,962 (0%)	0%		0	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	10,000	10,000	-		-	Stock Option (right to buy)
Kristin Abate	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	1,866	1,866	-		-	Stock Option (right to buy)
Kristin Abate	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2025	933	10,284 (0%)	0%		0	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 0.63 per share.	18 Feb 2025	5,914	320,714 (0%)	0%	0.6	3,726	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.65 per share.	04 Feb 2025	4,099	1,120,158 (1%)	0%	0.6	2,664	Common Stock
Lori Macomber	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Jan 2025	160,000	160,000 (0%)	0%		0	Common Stock
Lori Macomber	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Jan 2025	650,000	650,000	-		-	Stock Option (right to buy)
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.78 per share.	06 Jan 2025	4,055	1,124,257 (1%)	0%	0.8	3,175	Common Stock
Paulson Richard	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.81 per share.	04 Dec 2024	3,620	1,128,312 (1%)	0%	0.8	2,932	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.91 per share.	05 Nov 2024	3,675	1,131,932 (1%)	0%	0.9	3,346	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.88 per share.	04 Oct 2024	3,607	1,135,607 (1%)	0%	0.9	3,172	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 0.72 per share.	04 Sep 2024	7,050	391,054 (0%)	0%	0.7	5,089	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.72 per share.	04 Sep 2024	3,667	1,139,214 (1%)	0%	0.7	2,647	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Sale of securities on an exchange or to another person at price $ 0.72 per share.	04 Sep 2024	3,971	273,881 (0%)	0%	0.7	2,866	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 0.72 per share.	04 Sep 2024	5,356	404,051 (0%)	0%	0.7	3,866	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.93 per share.	06 Aug 2024	3,608	1,142,881 (1%)	0%	0.9	3,355	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 1.06 per share.	30 Jul 2024	2,883	326,628 (0%)	0%	1.1	3,056	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.85 per share.	05 Jul 2024	3,616	1,146,489 (1%)	0%	0.9	3,077	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.96 per share.	05 Jun 2024	463,518	346,615 (0%)	0%	1.0	444,143	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.95 per share.	05 Jun 2024	2,240	0 (0%)	0%	1.0	2,130	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.95 per share.	05 Jun 2024	229,308	0 (0%)	0%	1.0	218,003	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.98 per share.	05 Jun 2024	1,145	2,240 (0%)	0%	1.0	1,125	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.98 per share.	05 Jun 2024	117,307	229,308 (0%)	0%	1.0	115,289	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.96 per share.	05 Jun 2024	4,526	3,385 (0%)	0%	1.0	4,337	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 0.99 per share.	04 Jun 2024	652	398,104 (0%)	0%	1.0	645	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.99 per share.	04 Jun 2024	3,592	1,150,105 (1%)	0%	1.0	3,556	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.95 per share.	31 May 2024	3,298	7,911 (0%)	0%	1.0	3,140	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 1.00 per share.	31 May 2024	357,256	1,147,875 (1%)	0%	1.0	357,506	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.95 per share.	31 May 2024	1,976	14,697 (0%)	0%	1.0	1,885	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.95 per share.	31 May 2024	202,418	1,505,131 (2%)	0%	1.0	193,107	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 0.95 per share.	31 May 2024	337,742	810,133 (1%)	0%	1.0	321,564	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 1.00 per share.	31 May 2024	3,488	11,209 (0%)	0%	1.0	3,490	Common Stock
Barry E. Greene	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	69,000	69,000	-		-	Nonstatutory Stock Option (right to buy)
Chen Schor	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	69,000	69,000	-		-	Nonstatutory Stock Option (right to buy)
Garen G. Bohlin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	69,000	69,000	-		-	Nonstatutory Stock Option (right to buy)
Deepika Rachel Pakianathan	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	69,000	69,000	-		-	Nonstatutory Stock Option (right to buy)
Mansoor Raza Mirza	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	69,000	69,000	-		-	Nonstatutory Stock Option (right to buy)
Christy J. Oliger	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	69,000	69,000	-		-	Nonstatutory Stock Option (right to buy)
Zhen Su	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	50,587	50,587	-		-	Nonstatutory Stock Option (right to buy)
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.13 per share.	06 May 2024	3,576	1,153,697 (1%)	0%	1.1	4,041	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 1.17 per share.	22 Apr 2024	6,789	342,931 (0%)	0%	1.2	7,943	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.29 per share.	04 Apr 2024	3,563	1,157,273 (1%)	0%	1.3	4,596	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.30 per share.	05 Mar 2024	3,573	1,160,836 (1%)	0%	1.3	4,645	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 1.20 per share.	29 Feb 2024	6,162	398,756 (0%)	0%	1.2	7,394	Common
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 1.17 per share.	29 Feb 2024	27,687	404,918 (0%)	0%	1.2	32,394	Common
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.17 per share.	29 Feb 2024	80,470	1,183,783 (1%)	0%	1.2	94,150	Common
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.20 per share.	29 Feb 2024	19,374	1,164,409 (1%)	0%	1.2	23,249	Common
Reshma Rangwala	EVP & Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 1.17 per share.	29 Feb 2024	15,667	355,689 (0%)	0%	1.2	18,330	Common
Reshma Rangwala	EVP & Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 1.20 per share.	29 Feb 2024	5,969	349,720 (0%)	0%	1.2	7,163	Common
Michael Mano	SVP, General Counsel&Secretary	Sale of securities on an exchange or to another person at price $ 1.17 per share.	29 Feb 2024	16,973	281,428 (0%)	0%	1.2	19,858	Common
Michael Mano	SVP, General Counsel&Secretary	Sale of securities on an exchange or to another person at price $ 1.20 per share.	29 Feb 2024	3,576	277,852 (0%)	0%	1.2	4,291	Common
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 1.17 per share.	29 Feb 2024	21,840	398,618 (0%)	0%	1.2	25,553	Common
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 1.20 per share.	29 Feb 2024	5,109	393,509 (0%)	0%	1.2	6,131	Common
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 1.17 per share.	29 Feb 2024	16,311	335,666 (0%)	0%	1.2	19,084	Common
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 1.20 per share.	29 Feb 2024	6,155	329,511 (0%)	0%	1.2	7,386	Common
Roshan Cheng Sohanya	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2024	198,959	420,458 (0%)	0%		0	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2024	188,205	351,977 (0%)	0%		0	Common Stock
Paulson Richard	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2024	442,800	1,264,253 (1%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2024	147,000	298,401 (0%)	0%		0	Common Stock
Rangwala Reshma	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2024	198,959	371,356 (0%)	0%		0	Common Stock
Mason Michael	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2024	188,205	432,605 (0%)	0%		0	Common Stock
Mason Michael	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 1.32 per share.	27 Feb 2024	2,545	244,400 (0%)	0%	1.3	3,369	Common Stock
Poulton Stuart	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 1.40 per share.	15 Feb 2024	99	163,772 (0%)	0%	1.4	139	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 1.33 per share.	15 Feb 2024	5,748	163,871 (0%)	0%	1.3	7,645	Common Stock
Mason Michael	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 1.59 per share.	06 Feb 2024	4,205	246,945 (0%)	0%	1.6	6,671	Common Stock
Paulson Richard	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.59 per share.	06 Feb 2024	4,012	821,453 (1%)	0%	1.6	6,365	Common Stock
Cheng Sohanya Roshan	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jan 2024	14,167	221,499 (0%)	0%		0	Common Stock
Mason Michael	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jan 2024	13,333	251,150 (0%)	0%		0	Common Stock
Mano Michael	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jan 2024	9,167	151,401 (0%)	0%		0	Common Stock
Rangwala Reshma	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jan 2024	14,167	172,397 (0%)	0%		0	Common Stock
Paulson Richard	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jan 2024	42,000	825,465 (1%)	0%		0	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jan 2024	13,333	169,619 (0%)	0%		0	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.82 per share.	04 Jan 2024	4,114	783,465 (1%)	0%	0.8	3,373	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 0.79 per share.	04 Dec 2023	3,622	787,579 (1%)	0%	0.8	2,861	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.72 per share.	07 Aug 2023	3,722	802,018 (1%)	0%	1.7	6,402	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 1.70 per share.	28 Jul 2023	2,845	156,286 (0%)	0%	1.7	4,837	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 1.72 per share.	05 Jul 2023	3,538	805,740 (1%)	0%	1.7	6,085	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 2.35 per share.	08 Jun 2023	1,839	211,501 (0%)	0%	2.4	4,322	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 2.24 per share.	05 Jun 2023	3,536	809,278 (1%)	0%	2.2	7,922	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 2.22 per share.	02 Jun 2023	631	244,730 (0%)	0%	2.2	1,401	Common Stock
Barry E. Greene	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Chen Schor	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Garen G. Bohlin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Deepika Rachel Pakianathan	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Peter K. Honig	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Mansoor Raza Mirza	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Christy J. Oliger	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 May 2023	34,000	34,000	-		-	Nonstatutory Stock Option (right to buy)
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 3.35 per share.	04 May 2023	3,805	812,814 (1%)	0%	3.4	12,753	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 4.05 per share.	20 Apr 2023	6,655	158,230 (0%)	0%	4.1	26,953	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 4.03 per share.	20 Apr 2023	115	164,885 (0%)	0%	4.0	463	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 3.97 per share.	04 Apr 2023	3,497	816,619 (1%)	0%	4.0	13,883	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 3.16 per share.	06 Mar 2023	3,506	820,116 (1%)	0%	3.2	11,079	Common Stock
Michael Mason	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	95,000	256,566 (0%)	0%		0	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 3.03 per share.	28 Feb 2023	11,205	245,361 (0%)	0%	3.0	33,942	Common Stock
Stephen Mitchener	SVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	60,000	134,670 (0%)	0%		0	Common Stock
Stephen Mitchener	SVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 3.03 per share.	28 Feb 2023	6,357	128,313 (0%)	0%	3.0	19,257	Common Stock
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	252,000	856,655 (1%)	0%		0	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 3.03 per share.	28 Feb 2023	33,033	823,622 (1%)	0%	3.0	100,064	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	100,000	165,000 (0%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Sale of securities on an exchange or to another person at price $ 3.03 per share.	28 Feb 2023	6,878	146,122 (0%)	0%	3.0	20,835	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	70,000	153,000 (0%)	0%		0	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 3.03 per share.	28 Feb 2023	11,239	210,687 (0%)	0%	3.0	34,045	Common Stock
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	100,000	221,926 (0%)	0%		0	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2023	95,000	159,131 (0%)	0%		0	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 3.04 per share.	27 Feb 2023	2,802	161,566 (0%)	0%	3.0	8,509	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 3.19 per share.	15 Feb 2023	5,665	64,335 (0%)	0%	3.2	18,071	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 3.16 per share.	15 Feb 2023	196	64,131 (0%)	0%	3.2	619	Common Stock
Stuart Poulton	EVP, Chief Development Officer	Sale of securities on an exchange or to another person at price $ 3.25 per share.	15 Feb 2023	8	64,327 (0%)	0%	3.3	26	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 3.40 per share.	06 Feb 2023	4,141	164,368 (0%)	0%	3.4	14,079	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 3.40 per share.	06 Feb 2023	3,950	604,655 (0%)	0%	3.4	13,430	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 3.27 per share.	04 Jan 2023	3,922	608,605 (0%)	0%	3.3	12,825	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 5.17 per share.	05 Dec 2022	3,490	612,527 (0%)	0%	5.2	18,043	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 4.54 per share.	04 Nov 2022	3,493	616,017 (0%)	0%	4.5	15,858	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 5.87 per share.	04 Oct 2022	3,488	619,510 (0%)	0%	5.9	20,475	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 5.25 per share.	08 Sep 2022	16	626,461 (0%)	0%	5.3	84	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 5.23 per share.	08 Sep 2022	3,463	622,998 (0%)	0%	5.2	18,111	Common Stock
Michael Mason	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	45,000	45,000	-		-	Stock Option (right to buy)
Michael Mason	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	30,000	168,509 (0%)	0%		0	Common Stock
Stephen Mitchener	SVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	30,000	30,000	-		-	Stock Option (right to buy)
Stephen Mitchener	SVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	20,000	70,546 (0%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	20,000	83,000 (0%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	30,000	30,000	-		-	Stock Option (right to buy)
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	45,000	45,000	-		-	Stock Option (right to buy)
Sohanya Roshan Cheng	EVP & Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Aug 2022	30,000	119,949 (0%)	0%		0	Common Stock
Barry E. Greene	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Aug 2022	7,576	0	-		-	Stock Option (right to buy)
Barry E. Greene	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.48 per share.	11 Aug 2022	7,576	13,606 (0%)	0%	1.5	11,250	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 4.48 per share.	04 Aug 2022	2,314	626,477 (0%)	0%	4.5	10,367	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 5.18 per share.	08 Jul 2022	2,115	628,791 (0%)	0%	5.2	10,948	Common Stock
Sohanya Roshan Cheng	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 5.20 per share.	13 Jun 2022	1,485	89,949 (0%)	0%	5.2	7,722	Common Stock
Sohanya Roshan Cheng	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 5.35 per share.	13 Jun 2022	66	91,434 (0%)	0%	5.3	353	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 6.50 per share.	08 Jun 2022	322,825	1,918,298 (2%)	0%	6.5	2,099,428	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 6.00 per share.	08 Jun 2022	13	16,673 (0%)	0%	6	78	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 6.00 per share.	08 Jun 2022	1,294	1,707,549 (2%)	0%	6.0	7,766	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 6.18 per share.	08 Jun 2022	2,045	16,686 (0%)	0%	6.2	12,638	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 6.18 per share.	08 Jun 2022	209,455	1,708,843 (2%)	0%	6.2	1,294,390	Common Stock
Deepika Rachel Pakianathan	Director	Sale of securities on an exchange or to another person at price $ 6.50 per share.	08 Jun 2022	3,152	18,731 (0%)	0%	6.5	20,498	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 5.76 per share.	07 Jun 2022	2,542	630,906 (0%)	0%	5.8	14,642	Common Stock
Michael Mason	EVP, CFO, Treasurer	Sale of securities on an exchange or to another person at price $ 6.04 per share.	03 Jun 2022	598	138,512 (0%)	0%	6.0	3,612	Common Stock
Michael Mason	EVP, CFO, Treasurer	Sale of securities on an exchange or to another person at price $ 6.00 per share.	03 Jun 2022	3	138,509 (0%)	0%	6	18	Common Stock
Barry E. Greene	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Chen Schor	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Garen G. Bohlin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Deepika Rachel Pakianathan	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Peter K. Honig	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	10,995	10,995	-		-	Nonstatutory Stock Option (right to buy)
Mansoor Raza Mirza	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Christy J. Oliger	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 May 2022	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 6.26 per share.	04 May 2022	633	661,317 (1%)	0%	6.3	3,963	Common Stock
Richard Paulson	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 6.23 per share.	04 May 2022	27,869	633,448 (0%)	0%	6.2	173,546	Common Stock
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Apr 2022	100,000	100,000	-		-	Stock Option (right to buy)
Reshma Rangwala	EVP & Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Apr 2022	65,000	65,000 (0%)	0%		0	Common Stock
Sharon Shacham	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Mar 2022	60,000	958,131 (1%)	0%		0	Common Stock
Sharon Shacham	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Mar 2022	90,000	90,000	-		-	Stock Option (right to buy)
Michael Glen Kauffman	Director	Sale of securities on an exchange or to another person at price $ 10.24 per share.	28 Feb 2022	6,226	898,131 (1%)	0%	10.2	63,739	Common Stock
Michael Glen Kauffman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	27,000	27,000	-		-	Stock Option (right to buy)
Michael Glen Kauffman	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	21,000	719,983 (1%)	0%		0	Common Stock
Michael Glen Kauffman	Director	Sale of securities on an exchange or to another person at price $ 10.24 per share.	28 Feb 2022	6,226	713,757 (1%)	0%	10.2	63,739	Common Stock
Michael Mason	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	111,600	111,600	-		-	Stock Option (right to buy)
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 10.24 per share.	28 Feb 2022	2,398	139,110 (0%)	0%	10.2	24,550	Common Stock
Michael Mason	EVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	88,200	141,508 (0%)	0%		0	Common Stock
Sharon Shacham	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	27,000	27,000	-		-	Stock Option (right to buy)
Sharon Shacham	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	21,000	719,983 (1%)	0%		0	Common Stock
Sharon Shacham	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 10.24 per share.	28 Feb 2022	6,226	713,757 (1%)	0%	10.2	63,739	Common Stock
Sharon Shacham	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 10.24 per share.	28 Feb 2022	6,226	898,131 (1%)	0%	10.2	63,739	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	68,250	169,953 (0%)	0%		0	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	90,000	90,000	-		-	Stock Option (right to buy)
Ran Frenkel	EVP, Chief Dev. Officer	Sale of securities on an exchange or to another person at price $ 10.24 per share.	28 Feb 2022	1,663	168,290 (0%)	0%	10.2	17,025	Common Stock
Stephen Mitchener	SVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	59,400	59,400	-		-	Stock Option (right to buy)
Stephen Mitchener	SVP, Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	47,250	50,546 (0%)	0%		0	Common Stock
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	360,000	360,000	-		-	Stock Option (right to buy)
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	288,750	661,950 (1%)	0%		0	Common Stock
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	81,000	81,000	-		-	Stock Option (right to buy)
Michael Mano	SVP, General Counsel&Secretary	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	63,000	63,000 (0%)	0%		0	Common Stock
Sohanya Roshan Cheng	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	84,000	91,500 (0%)	0%		0	Common Stock
Sohanya Roshan Cheng	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Feb 2022	108,000	108,000	-		-	Stock Option (right to buy)
Michael Glen Kauffman	Director	Sale of securities on an exchange or to another person at price $ 12.12 per share.	17 Feb 2022	9,079	698,983 (1%)	0%	12.1	110,068	Common Stock
Michael Glen Kauffman	Director	Sale of securities on an exchange or to another person at price $ 12.12 per share.	17 Feb 2022	9,088	904,357 (1%)	0%	12.1	110,177	Common Stock
Sharon Shacham	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 12.12 per share.	17 Feb 2022	9,079	698,983 (1%)	0%	12.1	110,068	Common Stock
Sharon Shacham	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 12.12 per share.	17 Feb 2022	9,088	904,357 (1%)	0%	12.1	110,177	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Sale of securities on an exchange or to another person at price $ 12.12 per share.	17 Feb 2022	2,929	101,703 (0%)	0%	12.1	35,509	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 12.12 per share.	17 Feb 2022	1,306	129,450 (0%)	0%	12.1	15,833	Common Stock
Michael Glen Kauffman	Director	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	6,707	913,445 (1%)	0%	9.9	66,144	Common Stock
Michael Glen Kauffman	Director	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	6,764	708,062 (1%)	0%	9.9	66,707	Common Stock
Michael Mason	EVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	3,947	53,308 (0%)	0%	9.9	38,925	Common Stock
Sharon Shacham	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	6,764	708,062 (1%)	0%	9.9	66,707	Common Stock
Sharon Shacham	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	6,707	913,445 (1%)	0%	9.9	66,144	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	1,991	104,632 (0%)	0%	9.9	19,635	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 9.86 per share.	07 Feb 2022	1,704	130,756 (0%)	0%	9.9	16,805	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.73 per share.	12 Jul 2021	665	131,137 (0%)	0%	9.7	6,470	Common Stock
Sohanya Roshan Cheng	SVP Sales & Commercial Ops	Grant, award, or other acquisition of securities at price $ 0.00 per share.	30 Jun 2021	125,000	125,000	-		-	Nonstatutory Stock Option (right to buy)
Sohanya Roshan Cheng	SVP Sales & Commercial Ops	Grant, award, or other acquisition of securities at price $ 0.00 per share.	30 Jun 2021	7,500	7,500 (0%)	0%		0	Common Stock
Stephen Mitchener	SVP, Chief Business Officer	Sale of securities on an exchange or to another person at price $ 9.29 per share.	02 Jun 2021	528	2,472 (0%)	0%	9.3	4,905	Common Stock
Michael Mason	EVP, CFO, Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jun 2021	5,500	57,255 (0%)	0%		0	Common Stock
Michael Mason	EVP, CFO, Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jun 2021	15,000	15,000	-		-	Stock Option (right to buy)
Stephen Mitchener	SVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 May 2021	1,500	1,500	-		-	Restricted Stock Units
Stephen Mitchener	SVP, Chief Business Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 May 2021	1,500	3,000 (0%)	0%		-	Common Stock
Barry E. Greene	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Chen Schor	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Garen G. Bohlin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Deepika Rachel Pakianathan	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Mikael Dolsten	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Mansoor Raza Mirza	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Christy J. Oliger	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2021	23,900	23,900	-		-	Nonstatutory Stock Option (right to buy)
Jatin Shah	EVP, Chief Medical Officer	Purchase of securities on an exchange or from another person at price $ 8.60 per share.	07 May 2021	23,250	131,802 (0%)	0%	8.6	199,992	Common Stock
Garen G. Bohlin	Director	Purchase of securities on an exchange or from another person at price $ 7.82 per share.	06 May 2021	4,000	4,000 (0%)	0%	7.8	31,280	Common Stock
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 May 2021	559,800	559,800	-		-	Stock Option (right to buy)
Richard Paulson	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 May 2021	373,200	373,200 (0%)	0%		0	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 12.39 per share.	18 Mar 2021	4,000	714,826 (1%)	0%	12.4	49,553	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 12.39 per share.	18 Mar 2021	4,000	714,826 (1%)	0%	12.4	49,553	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	57,200	718,826 (1%)	0%		0	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	153,500	153,500	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	153,500	153,500	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	57,200	920,152 (1%)	0%		0	Common Stock
Tanya Lewis	EVP, Chief Reg. Affairs	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	22,013	45,401 (0%)	0%		0	Common Stock
Tanya Lewis	EVP, Chief Reg. Affairs	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	59,968	59,968	-		-	Stock Option (right to buy)
Michael Mason	SVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	22,013	51,755 (0%)	0%		0	Common Stock
Michael Mason	SVP, CFO & Treasurer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	59,968	59,968	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	57,200	920,152 (1%)	0%		0	Common Stock
Sharon Shacham	President & CSO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	153,500	153,500	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	153,500	153,500	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	57,200	718,826 (1%)	0%		0	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	22,013	104,439 (0%)	0%		0	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	59,968	59,968	-		-	Stock Option (right to buy)
John Demaree	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	15,849	23,995 (0%)	0%		0	Common Stock
John Demaree	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	43,177	43,177	-		-	Stock Option (right to buy)
Jatin Shah	EVP, Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	59,968	59,968	-		-	Stock Option (right to buy)
Jatin Shah	EVP, Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Feb 2021	22,013	107,691 (0%)	0%		0	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 14.83 per share.	18 Feb 2021	9,495	575,126 (0%)	0%	14.8	140,822	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 14.83 per share.	18 Feb 2021	9,495	776,452 (1%)	0%	14.8	140,822	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 14.83 per share.	18 Feb 2021	9,495	776,452 (1%)	0%	14.8	140,822	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 14.83 per share.	18 Feb 2021	9,495	575,126 (0%)	0%	14.8	140,822	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Sale of securities on an exchange or to another person at price $ 14.83 per share.	18 Feb 2021	2,887	46,126 (0%)	0%	14.8	42,818	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 14.83 per share.	18 Feb 2021	1,186	51,791 (0%)	0%	14.8	17,590	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	6,601	562,821 (0%)	0%	15.5	102,441	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	43,600	-		-	Restricted Stock Units
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	43,600	-		-	Restricted Stock Units
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	785,947 (1%)	0%		-	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	6,642	764,147 (1%)	0%	15.5	103,077	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	584,621 (0%)	0%		-	Common Stock
Tanya Lewis	EVP, Chief Reg. Affairs	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	2,046	4,143 (0%)	0%	15.5	31,752	Common Stock
Michael Mason	SVP, CFO & Treasurer	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	2,858	5,292 (0%)	0%	15.5	44,354	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	6,642	764,147 (1%)	0%	15.5	103,077	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	43,600	-		-	Restricted Stock Units
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	43,600	-		-	Restricted Stock Units
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	584,621 (0%)	0%		-	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	6,601	562,821 (0%)	0%	15.5	102,441	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	21,800	785,947 (1%)	0%		-	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	9,675	19,350	-		-	Restricted Stock Units
Ran Frenkel	EVP, Chief Dev. Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	9,675	49,013 (0%)	0%		-	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	2,046	39,338 (0%)	0%	15.5	31,752	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	4,850	9,700	-		-	Restricted Stock Units
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Feb 2021	4,850	52,977 (0%)	0%		-	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 15.52 per share.	11 Feb 2021	1,748	48,127 (0%)	0%	15.5	27,127	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	770,789 (1%)	0%		-	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	42,900	-		-	Restricted Stock Units
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	42,900	-		-	Restricted Stock Units
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	569,422 (0%)	0%		-	Common Stock
Tanya Lewis	EVP, Chief Reg. Affairs	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	5,650	6,189 (0%)	0%		-	Common Stock
Tanya Lewis	EVP, Chief Reg. Affairs	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	5,650	16,950	-		-	Restricted Stock Units
Michael Mason	SVP, CFO & Treasurer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	8,150	24,450	-		-	Restricted Stock Units
Michael Mason	SVP, CFO & Treasurer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	8,150	8,150 (0%)	0%		-	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	770,789 (1%)	0%		-	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	42,900	-		-	Restricted Stock Units
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	42,900	-		-	Restricted Stock Units
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	14,300	569,422 (0%)	0%		-	Common Stock
Ran Frenkel	EVP, Chief Dev. Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	5,650	16,950	-		-	Restricted Stock Units
Ran Frenkel	EVP, Chief Dev. Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	5,650	41,384 (0%)	0%		-	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	5,650	49,875 (0%)	0%		-	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Feb 2021	5,650	16,950	-		-	Restricted Stock Units
Mansoor Raza Mirza	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.43 per share.	18 Dec 2020	5,000	5,000 (0%)	0%	5.4	27,150	Common Stock
Mansoor Raza Mirza	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	18 Dec 2020	5,000	0	-		-	Stock Option (right to buy)
Mansoor Raza Mirza	Director	Sale of securities on an exchange or to another person at price $ 18.00 per share.	18 Dec 2020	5,000	0 (0%)	0%	18	90,000	Common Stock
Mansoor Raza Mirza	Director	Sale of securities on an exchange or to another person at price $ 16.04 per share.	07 Dec 2020	5,000	5,000 (0%)	0%	16.0	80,223	Common Stock
Mansoor Raza Mirza	Director	Sale of securities on an exchange or to another person at price $ 16.05 per share.	07 Dec 2020	5,000	10,000 (0%)	0%	16.0	80,227	Common Stock
Mansoor Raza Mirza	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.43 per share.	07 Dec 2020	20,000	20,000 (0%)	0%	5.4	108,600	Common Stock
Mansoor Raza Mirza	Director	Sale of securities on an exchange or to another person at price $ 16.05 per share.	07 Dec 2020	5,000	15,000 (0%)	0%	16.0	80,231	Common Stock
Mansoor Raza Mirza	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Dec 2020	20,000	5,000	-		-	Stock Option (right to buy)
Mansoor Raza Mirza	Director	Sale of securities on an exchange or to another person at price $ 16.14 per share.	07 Dec 2020	5,000	0 (0%)	0%	16.1	80,704	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.45 per share.	01 Dec 2020	78,124	82,647 (0%)	0%	10.5	816,396	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2020	58,937	16,842	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2020	78,124	46,876	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 17.35 per share.	01 Dec 2020	58,937	4,523 (0%)	0%	17.4	1,022,557	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.39 per share.	01 Dec 2020	58,937	63,460 (0%)	0%	10.4	612,355	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 17.66 per share.	01 Dec 2020	78,124	4,523 (0%)	0%	17.7	1,379,670	Common Stock
Chen Schor	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 Nov 2020	32,800	32,800	-		-	Nonstatutory Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 14.92 per share.	02 Nov 2020	772	4,523 (0%)	0%	14.9	11,518	Common Stock
Tanya Lewis	EVP,Chief Reg.&Quality Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Oct 2020	765	2,295	-		-	Restricted Stock Units
Tanya Lewis	EVP,Chief Reg.&Quality Officer	Sale of securities on an exchange or to another person at price $ 15.58 per share.	28 Oct 2020	226	539 (0%)	0%	15.6	3,521	Common Stock
Tanya Lewis	EVP,Chief Reg.&Quality Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Oct 2020	765	765 (0%)	0%		-	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Oct 2020	38,550	64,250	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Oct 2020	721	75,779	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 17.20 per share.	13 Oct 2020	721	4,649 (0%)	0%	17.2	12,401	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.39 per share.	13 Oct 2020	721	5,370 (0%)	0%	10.4	7,491	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 16.85 per share.	13 Oct 2020	38,550	4,649 (0%)	0%	16.9	649,568	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.21 per share.	13 Oct 2020	38,550	43,199 (0%)	0%	9.2	355,046	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	12 Oct 2020	1,424	757,913 (1%)	0%	0.0	47	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	12 Oct 2020	6,076	763,989 (1%)	0%	0.0	201	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 14.89 per share.	12 Oct 2020	7,500	756,489 (1%)	0%	14.9	111,683	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Oct 2020	6,076	0	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Oct 2020	1,424	0	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	12 Oct 2020	1,424	757,913 (1%)	0%	0.0	47	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Oct 2020	1,424	0	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 14.89 per share.	12 Oct 2020	7,500	756,489 (1%)	0%	14.9	111,683	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	12 Oct 2020	6,076	763,989 (1%)	0%	0.0	201	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Oct 2020	6,076	0	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.54 per share.	08 Sep 2020	10,054	14,703 (0%)	0%	6.5	65,753	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 14.98 per share.	08 Sep 2020	10,054	4,649 (0%)	0%	15.0	150,609	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Sep 2020	10,054	0	-		-	Stock Option (right to buy)
Christy J. Oliger	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	28 Aug 2020	32,800	32,800	-		-	Nonstatutory Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Aug 2020	1,477	6,076	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 15.00 per share.	17 Aug 2020	1,477	756,489 (1%)	0%	15	22,155	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	17 Aug 2020	1,477	757,966 (1%)	0%	0.0	49	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	17 Aug 2020	1,477	757,966 (1%)	0%	0.0	49	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 15.00 per share.	17 Aug 2020	1,477	756,489 (1%)	0%	15	22,155	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Aug 2020	1,477	6,076	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 Jul 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2020	7,500	1,424	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 19.43 per share.	15 Jul 2020	7,500	756,489 (1%)	0%	19.4	145,723	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2020	7,500	1,424	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 19.43 per share.	15 Jul 2020	7,500	756,489 (1%)	0%	19.4	145,723	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 Jul 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Jul 2020	2,413	7,237	-		-	Restricted Stock Units
Jatin Shah	EVP, Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 19.46 per share.	11 Jul 2020	589	43,229 (0%)	0%	19.5	11,462	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Jul 2020	2,413	43,172 (0%)	0%		-	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 18.98 per share.	09 Jul 2020	7,200	555,422 (0%)	0%	19.0	136,627	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jul 2020	7,500	377,803	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jul 2020	7,500	333,561	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 19.53 per share.	09 Jul 2020	7,500	756,489 (1%)	0%	19.5	146,487	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jul 2020	7,500	763,989 (1%)	0%	4.8	35,640	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 19.71 per share.	09 Jul 2020	300	555,122 (0%)	0%	19.7	5,912	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jul 2020	7,500	562,622 (0%)	0%	4.8	35,640	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 19.53 per share.	09 Jul 2020	7,500	756,489 (1%)	0%	19.5	146,487	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jul 2020	7,500	333,561	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jul 2020	7,500	377,803	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 19.71 per share.	09 Jul 2020	300	555,122 (0%)	0%	19.7	5,912	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 18.98 per share.	09 Jul 2020	7,200	555,422 (0%)	0%	19.0	136,627	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jul 2020	7,500	562,622 (0%)	0%	4.8	35,640	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jul 2020	7,500	763,989 (1%)	0%	4.8	35,640	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 20.00 per share.	22 Jun 2020	7,500	756,489 (1%)	0%	20	150,000	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Jun 2020	7,500	8,924	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	22 Jun 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 20.00 per share.	22 Jun 2020	7,500	756,489 (1%)	0%	20	150,000	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Jun 2020	7,500	8,924	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	22 Jun 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 Jun 2020	357	756,846 (1%)	0%	0.0	12	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jun 2020	357	0	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jun 2020	7,143	16,424	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 16.20 per share.	15 Jun 2020	357	756,489 (1%)	0%	16.2	5,783	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 16.38 per share.	15 Jun 2020	7,143	756,489 (1%)	0%	16.4	116,996	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 Jun 2020	7,143	763,632 (1%)	0%	0.0	236	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 Jun 2020	7,143	763,632 (1%)	0%	0.0	236	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jun 2020	357	0	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jun 2020	7,143	16,424	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 16.20 per share.	15 Jun 2020	357	756,489 (1%)	0%	16.2	5,783	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 Jun 2020	357	756,846 (1%)	0%	0.0	12	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 16.38 per share.	15 Jun 2020	7,143	756,489 (1%)	0%	16.4	116,996	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 18.13 per share.	09 Jun 2020	7,500	555,122 (0%)	0%	18.1	135,944	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jun 2020	7,500	385,303	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jun 2020	7,500	341,061	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 18.50 per share.	09 Jun 2020	7,500	756,489 (1%)	0%	18.5	138,746	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jun 2020	7,500	763,989 (1%)	0%	4.8	35,640	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jun 2020	7,500	562,622 (0%)	0%	4.8	35,640	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 18.50 per share.	09 Jun 2020	7,500	756,489 (1%)	0%	18.5	138,746	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jun 2020	7,500	341,061	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Jun 2020	7,500	385,303	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 18.13 per share.	09 Jun 2020	7,500	555,122 (0%)	0%	18.1	135,944	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jun 2020	7,500	562,622 (0%)	0%	4.8	35,640	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Jun 2020	7,500	763,989 (1%)	0%	4.8	35,640	Common Stock
Barry E. Greene	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2020	16,400	16,400	-		-	Nonstatutory Stock Option (right to buy)
Garen G. Bohlin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2020	16,400	16,400	-		-	Nonstatutory Stock Option (right to buy)
Deepika Rachel Pakianathan	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2020	16,400	16,400	-		-	Nonstatutory Stock Option (right to buy)
Mikael Dolsten	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2020	16,400	16,400	-		-	Nonstatutory Stock Option (right to buy)
Mansoor Raza Mirza	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2020	16,400	16,400	-		-	Nonstatutory Stock Option (right to buy)
Richard Paulson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2020	16,400	16,400	-		-	Nonstatutory Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 May 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 May 2020	7,500	357	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 May 2020	7,500	7,857	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 18.65 per share.	15 May 2020	7,500	756,489 (1%)	0%	18.6	139,841	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 May 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 20.00 per share.	15 May 2020	7,500	756,489 (1%)	0%	20	150,000	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 18.65 per share.	15 May 2020	7,500	756,489 (1%)	0%	18.6	139,841	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 May 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	15 May 2020	7,500	763,989 (1%)	0%	0.0	248	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 20.00 per share.	15 May 2020	7,500	756,489 (1%)	0%	20	150,000	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 May 2020	7,500	7,857	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 May 2020	7,500	357	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	07 May 2020	7,500	562,622 (0%)	0%	4.8	35,640	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 May 2020	7,500	392,803	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 May 2020	7,500	348,561	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 19.63 per share.	07 May 2020	7,500	756,489 (1%)	0%	19.6	147,205	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	07 May 2020	7,500	763,989 (1%)	0%	4.8	35,640	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 19.63 per share.	07 May 2020	7,500	555,122 (0%)	0%	19.6	147,209	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 May 2020	7,500	348,561	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 May 2020	7,500	392,803	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 19.63 per share.	07 May 2020	7,500	555,122 (0%)	0%	19.6	147,209	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	07 May 2020	7,500	562,622 (0%)	0%	4.8	35,640	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 19.63 per share.	07 May 2020	7,500	756,489 (1%)	0%	19.6	147,205	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	07 May 2020	7,500	763,989 (1%)	0%	4.8	35,640	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 May 2020	2,946	10,054	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 20.00 per share.	07 May 2020	2,946	4,649 (0%)	0%	20	58,920	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.54 per share.	07 May 2020	2,946	7,595 (0%)	0%	6.5	19,267	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 19.62 per share.	07 May 2020	6,714	4,649 (0%)	0%	19.6	131,707	Common Stock
Ran Frenkel	Chief Dev Operations Officer	Sale of securities on an exchange or to another person at price $ 20.00 per share.	07 May 2020	1,974	35,088 (0%)	0%	20	39,480	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 20.64 per share.	08 Apr 2020	10,000	555,122 (0%)	0%	20.6	206,404	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Apr 2020	10,000	400,303	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Apr 2020	10,000	356,061	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 18.61 per share.	08 Apr 2020	10,000	756,489 (1%)	0%	18.6	186,115	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	08 Apr 2020	10,000	766,489 (1%)	0%	4.8	47,520	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	08 Apr 2020	10,000	565,122 (0%)	0%	4.8	47,520	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 18.61 per share.	08 Apr 2020	10,000	756,489 (1%)	0%	18.6	186,115	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Apr 2020	10,000	356,061	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	08 Apr 2020	10,000	400,303	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 20.64 per share.	08 Apr 2020	10,000	555,122 (0%)	0%	20.6	206,404	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	08 Apr 2020	10,000	565,122 (0%)	0%	4.8	47,520	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	08 Apr 2020	10,000	766,489 (1%)	0%	4.8	47,520	Common Stock
Barry E. Greene	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Mar 2020	3,030	0	-		-	Stock Option (right to buy)
Barry E. Greene	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.03 per share.	13 Mar 2020	3,030	6,030 (0%)	0%	0.0	100	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Mar 2020	10,000	565,122 (0%)	0%	4.8	47,520	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2020	10,000	410,303	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2020	10,000	366,061	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 22.38 per share.	09 Mar 2020	3,000	756,489 (1%)	0%	22.4	67,141	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 22.58 per share.	09 Mar 2020	7,000	759,489 (1%)	0%	22.6	158,054	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Mar 2020	10,000	766,489 (1%)	0%	4.8	47,520	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 22.64 per share.	09 Mar 2020	2,068	555,122 (0%)	0%	22.6	46,821	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 22.11 per share.	09 Mar 2020	7,932	557,190 (0%)	0%	22.1	175,365	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Mar 2020	10,000	766,489 (1%)	0%	4.8	47,520	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2020	10,000	366,061	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Mar 2020	10,000	410,303	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 22.64 per share.	09 Mar 2020	2,068	555,122 (0%)	0%	22.6	46,821	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 22.11 per share.	09 Mar 2020	7,932	557,190 (0%)	0%	22.1	175,365	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	09 Mar 2020	10,000	565,122 (0%)	0%	4.8	47,520	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 22.38 per share.	09 Mar 2020	3,000	756,489 (1%)	0%	22.4	67,141	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 22.58 per share.	09 Mar 2020	7,000	759,489 (1%)	0%	22.6	158,054	Common Stock
Richard Paulson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Mar 2020	50,000	50,000	-		-	Nonstatutory Stock Option (right to buy)
Mansoor Raza Mirza	Director	Sale of securities on an exchange or to another person at price $ 23.50 per share.	02 Mar 2020	5,000	0 (0%)	0%	23.5	117,500	Common Stock
Mansoor Raza Mirza	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Mar 2020	5,000	0	-		-	Stock Option (right to buy)
Mansoor Raza Mirza	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.06 per share.	02 Mar 2020	5,000	5,000 (0%)	0%	8.1	40,300	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 28.00 per share.	02 Mar 2020	10,000	19,367 (0%)	0%	28	280,000	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 23.50 per share.	02 Mar 2020	7,500	29,367 (0%)	0%	23.5	176,250	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.39 per share.	02 Mar 2020	26,500	36,867 (0%)	0%	10.4	275,335	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Mar 2020	26,500	76,500	-		-	Stock Option (right to buy)
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 24.00 per share.	02 Mar 2020	9,000	10,367 (0%)	0%	24.0	216,029	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	8,817	555,122 (0%)	0%	16.5	145,321	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	8,817	756,489 (1%)	0%	16.5	145,321	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	8,817	756,489 (1%)	0%	16.5	145,321	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	8,817	555,122 (0%)	0%	16.5	145,321	Common Stock
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	2,961	10,367 (0%)	0%	16.5	48,803	Common Stock
Ran Frenkel	Chief Dev Operations Officer	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	2,975	36,066 (0%)	0%	16.5	49,034	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 16.48 per share.	19 Feb 2020	1,375	40,759 (0%)	0%	16.5	22,663	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	65,400	-		-	Restricted Stock Units
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	563,939 (0%)	0%		-	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	765,306 (1%)	0%		-	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	65,400	-		-	Restricted Stock Units
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	65,400	-		-	Restricted Stock Units
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	765,306 (1%)	0%		-	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	563,939 (0%)	0%		-	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	21,800	65,400	-		-	Restricted Stock Units
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	9,675	29,025	-		-	Restricted Stock Units
Christopher Brett Primiano	EVP, CBO, GC & Secretary	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	9,675	13,328 (0%)	0%		-	Common Stock
Ran Frenkel	Chief Dev Operations Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	9,675	29,025	-		-	Restricted Stock Units
Ran Frenkel	Chief Dev Operations Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	9,675	39,041 (0%)	0%		-	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	4,850	42,134 (0%)	0%		-	Common Stock
Jatin Shah	EVP, Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2020	4,850	14,550	-		-	Restricted Stock Units
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Feb 2020	10,000	376,061	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Feb 2020	10,000	420,303	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	10 Feb 2020	10,000	552,139 (0%)	0%	4.8	47,520	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	10 Feb 2020	10,000	753,506 (1%)	0%	4.8	47,520	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 17.43 per share.	10 Feb 2020	10,000	542,139 (0%)	0%	17.4	174,294	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Sale of securities on an exchange or to another person at price $ 16.93 per share.	10 Feb 2020	10,000	743,506 (1%)	0%	16.9	169,327	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Feb 2020	10,000	376,061	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Feb 2020	10,000	420,303	-		-	Stock Option (right to buy)
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 17.43 per share.	10 Feb 2020	10,000	542,139 (0%)	0%	17.4	174,294	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	10 Feb 2020	10,000	552,139 (0%)	0%	4.8	47,520	Common Stock
Sharon Shacham	President & CSO	Sale of securities on an exchange or to another person at price $ 16.93 per share.	10 Feb 2020	10,000	743,506 (1%)	0%	16.9	169,327	Common Stock
Sharon Shacham	President & CSO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.75 per share.	10 Feb 2020	10,000	753,506 (1%)	0%	4.8	47,520	Common Stock
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Feb 2020	153,500	153,500	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Feb 2020	153,500	153,500	-		-	Stock Option (right to buy)
Michael G. Kauffman	Director, Chief Executive Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	05 Feb 2020	57,200	57,200	-		-	Restricted Stock Units

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

74.06% Fall from 52W High

Insider Trading disclosures for Karyopharm Therapeutics Inc

The latest disclosure was made by Richard Paulson in Karyopharm Therapeutics Inc where a trade of 11,694 Common Stock done at an average price of $6.3 was reported to US exchanges on March 4, 2025.

Screeners based on Insider Trading and SAST parameters